Here is, yet another, ‘mysterious’ drug side effect that will never be attributed to the true cause – magnesium deficiency.
On Aug 28, 2015, a Medscape Article reported that Dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes can cause disabling joint pain. Most of the cases involve Januvia (sitagliptin) probably because this drug accounts for more than 80% of all DPP-4 prescriptions netting $6 Billion in world wide sales.
What they don’t tell you is why the drug has this side effect. Is it because they just don’t know or are they ignoring the fact that magnesium deficiency may be the cause?
The company that makes Januvia defends the drug in terms of risk/benefit ratio. However, the old ‘you win some, you lose some’ scenario doesn’t fit my definition of First Do No Harm. They don’t deny the drug has side effects but they argue that not that many people are harmed and the drug has more benefits than risks. That’s no consolation to the person who is hit with this side effect. And, there is no way of knowing who will suffer. Also, they don’t consider that one major sign of diabetes is magnesium deficiency and often just treating with a well-absorbed magnesium (ReMag) alone will lower blood sugars. Add to magnesium, chromium, zinc and a half-dozen other minerals and you have a good chance of treating your diabetes naturally. My ReMyte formula contains all these minerals.
Drug researchers don’t seem to be aware that Januvia’s 6 fluoride molecules could be the problem. Ciprofloxacin only has 1 fluoride molecule and an official FDA black box warning that it can cause tendinitis and tendon rupture, which I say is due to the fluoride. When will Januvia be issued its own black box warning?
Correspondence that I recently had with a microbiologist confirmed that researchers are not trying to find out whether the fluoride molecules in dozens of drugs are binding magnesium and causing magnesium deficiency side effects. She and other scientists say that the covalent fluoride-carbon bond in drugs, refrigerants and pesticides is stable and apparently doesn’t release free fluoride in lab animals. However, she noted that the effect of intestinal bacteria on fluoride compounds has never been examined. Bacteria have the ability to metabolize fluoride compounds, possibly releasing more toxic forms of the partially degraded drug.
She said that another problem is that drugs are safety-tested individually in relatively short-term animal experiments. It’s only recently that toxicology is finally beginning to pay attention to multiple, simultaneous exposures, which are very common and can have additive or synergistic effects. Thus, the overall fluoride exposure in people may be much greater than studied for any single fluoride drug during clinical trials. They will also have to take into account fluoride in the water and in most dental products and unnecessary fluoride treatments in a dentist’s office.
Of course doctors never measure ionized magnesium in patients to see who may already be magnesium-deficient and who may be the first to suffer drug side effects. I’m sure drug companies know that magnesium if affected by drugs but it’s not patented and if drug companies add magnesium to their drugs, they might be afraid that patients will get the wrong idea and just take it instead of the drugs.
Mildred Seelig MD, a magnesium expert (now deceased) told me that many decades ago her first job out of medical school was with a drug company. They wanted to know what happens to vitamins and minerals when people take drugs. One consistent finding was an elevation of serum magnesium with each drug dose. Dr. Seelig told her superiors, who ignored her, but the findings wouldn’t go away.
She said in a telephone conversation that she had a revelatory insight that drugs force magnesium to come out of storage – perhaps to detoxify the drugs – but in doing so, a person might feel benefits from the extra magnesium, not from the drug. However, after about 6-8 weeks, a person’s magnesium stores are depleted and the drug side effects surface along with symptoms of magnesium deficiency. That may be why drug trials are often in the 6-8 week range. After this realization, she quit that job and made magnesium her life’s work.
Once again I’m making the point that drugs deplete magnesium and drug companies don’t let you in on this secret. Your best course of action is to stay healthy by taking magnesium. Of course, I recommend ReMag, which is 100% absorbed at the cellular level, has no laxative effects and is astoundingly therapeutic. Along with the other Total Body ReSet formulas we are seeing miraculous results.
Carolyn Dean MD ND
The Doctor of the Future™
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