Scientists, in their latest attempt to control your body, want to manipulate the following enzymes to treat diabetes: Calcium /Calcium-modulated Dependent Protein Kinase I and II (CaM kinase II and CaMKII).
Here’s the researchers’ preliminary evidence. In one experiment in obese mice, they found that no matter how CaMKII was knocked out, it led to lower blood glucose levels and lower fasting plasma insulin levels in response to a glucose challenge. They concluded that this enzyme plays an important role in the development of hyperglycemia and hyperinsulinemia in obese mice.
Their recommendation: LETS KILL THIS ENZYME
Here’s my thinking. Any enzyme controlled by calcium is naturally balanced by magnesium. So, if they think CaMKII is malfunctioning, just hit it with magnesium to rebalance it – DON’T KILL IT.
Why is it a BAD idea to Kill CaMKII? Because CaMKII does MUCH more than help to control blood sugar. It is important in learning and memory; necessary for calcium homeostasis and calcium reuptake in heart muscle cells; positive T-cell selection; CD8 T-cell activation; neurotransitter secretion; transcription factor regulation; and glycogen metabolism. Misregulation of CaMKII is linked to deranged myosin phosphorylation (myosins: ATP-dependent proteins creating muscle contraction), imbalanced smooth muscle contraction, heart arrhythmia, Alzheimer’s disease and Angelman Syndrome (a neuro-genetic disorder characterized by severe intellectual and development disability, sleep disturbance, seizures, jerky movements (especially hand-flapping), frequent laughter or smiling, and usually a happy demeanor).
If you know anything about magnesium you know it’s involved with everything in the above paragraph. Imagine me Screaming now – “Lord Suffering Cats, why are scientists trying to find a drug to KILL this enzyme instead of just using magnesium?” When they do make their drugs to kill this enzyme, I can guarantee they are going to cause arrhythmia, insomnia, seizures and many more magnesium deficiency symptoms.
It only took me a few moments to find a study showing that “…magnesium depleted rats experience spontaneous epileptiform (seizure) activity and simultaneous changes in CaM kinase II activity.” And another study in 1985 focused on balancing the kinase enzymes with magnesium. They concluded that: “magnesium is an important coherent controller of glycolysis and the Krebs cycle. Many of the glycolytic kinase enzymes are sensitive to Mg2+.”
This scenario reminds me of a 2012 study in Neuropharmacology, it initially sounded promising “Magnesium Induces Anxiety and HPT Axis Dysregulation” but then the second part of the title “Modulation by Therapeutic Drug Treatment” made no sense at all.
I’ve written a paper for the Nutritional Magnesium Association on this study. I’ll let you know when it is published. In the meantime, think about the insanity of treating magnesium-induced anxiety and and hormone dysregulation with antidepressant drugs. What would you use instead? How about MAGNESIUM?
Carolyn Dean MD ND
The Doctor of the Future®
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