After reading my Lady Gaga Feels Your Pain blog, someone reminded me that Fluroquinolone toxicity can be misdiagnosed as fibromyalgia. Fluoroquinolone forums are saying that these drugs leech minerals from the body and magnesium deficiency is a known marker. This reader wondered if Fluoroquinolone toxicity, which is already known to be associated with mitochondrial damage, has anything to do with magnesium deficiency.
Lord Sufferin’ Cats. Yes!!
But you’re not going to hear this from most doctors because they don’t know how intimately magnesium is involved in mitochondrial function. Actually they don’t know much about magnesium at all!!
You may have heard me say that mitochrondria are responsible for making ATP energy in the body – the stuff that keeps us awake and alive and out of bed. Inside the mito the Krebs cycle churns away making ATP in 8 biochemical steps, six of which require magnesium. Bottom line – no magnesium, no energy! This combination of ATP and magnesium triggers production of the body’s protein structures by revving up messenger RNA. And ATP-Mg is also a requirement for the production of DNA.
There are 1,000 to 2,000 mitochondria in every cell in the body (except red blood cells and skin cells) during energy production they create waste products called reactive oxygen species (ROSs) that include free radicals. A build up of ROSs can damage mitochondrial DNA. And what protects cells and mitochrondria from ROS damage?
That’s right! Magnesium.
What makes ROS damage worse?
Here’s how Dr. Guy Abraham describes the problem of too much calcium in mitochondria. In order to protect the fluid inside cells from becoming overly saturated with calcium, there is a magnesium-dependent mechanism that shunts calcium into the mitochondria. It’s meant for short-term use only, so it can backfire because if too much calcium is taken up for too long, the excess calcium in the mitochondria inhibits ATP synthesis. Mitochondrial calcification without the intervention of sufficient magnesium eventually results in cell death.
My question is: Beyond the absolute need for magnesium to make ATP, could calcium excess and magnesium deficiency be the underlying cause of mitochondrial dysfunction that many natural medicine practitioners say can trigger chronic fatigue syndrome, fibromyalgia, and other chronic diseases? If so, the obvious treatment would be to limit calcium intake and increase magnesium supplementation to the point of saturation.
Not surprisingly the following nutrients that support mitochondrial function are all covered in Total Body ReSet!
- B-complex – (methylated B’s in ReAline)
- Magnesium (ReMag)
- Zinc (ReMyte)
- Manganese (ReMyte)
- Glutathione (L-methionine in ReAline and whey in ReStructure are glutathione precursors)
You may see other products being promoted for mitochondrial health but they are usually antioxidants to deal with mito ROS waste, they are not the mineral and vitamin cofactors in the Krebs cycle itself. I think mito waste is best eliminated by magnesium and ReAline.
Carolyn Dean MD ND
The Doctor of the Future®
RESOURCES: Along the borders and in the links of my web site you can find my books, writings, and my call-in radio show. Email your questions to: firstname.lastname@example.org.