Complex Metabolic Patients  - Dr. Carolyn Dean MD ND

Complex Metabolic Patients 

July 14, 2019
A Medscape Continuing Medical Education Case Study introduced the topic of Complex Metabolic Patients. What does allopathic medicine recommend to deal with metabolic complexity where patients suffer a dangerous combination of high blood pressure, high cholesterol, diabetes, obesity, and heart disease? Their solution is to educate doctors to “improve statin management in patients with complex metabolic disease by using patient-centered strategies to minimize glucose and new-onset diabetes risks as well as statin intolerance.” They also announce that “…we have 9 classes of medications now that have outcomes data to show reduced risk of CVD.”
How many times have I sounded the death knell of statins? Probably over one hundred times in various articles, blogs, books and radio shows. But statins are still the “go to” drug of allopathetic medicine! 
Here’s a common scenario that I’ve heard from countless patients. You’ve been under even more stress than usual but it’s time for your annual physical. Your blood pressure is high but it’s always a bit high when you go to the doctor. However, the new physician’s assistant (PA) looks at your chart and insists that it’s time you took medication because it was only going to get worse with age. You are scared by what the PA says and take the prescription for a diuretic (that depletes magnesium) and go back for a follow up visit in a month. Your blood pressure is even higher and the PA says “Look, we caught it just in time, but now you need two more drugs.” both of which cause magnesium deficiency. After another two months you go back for blood tests to make sure your liver can handle the drugs and “out of the blue” your cholesterol and blood sugar are both high for the first time. The PA says it’s just part of the disease progression and puts you on another 2-3 drugs. It’s the downward spiral of magnesium-deficiency-induced heart disease. That spiral will keep spinning out of control unless you begin taking therapeutic amounts of magnesium and work with your doctor to slowly wean off these unnecessary medications.
I, personally define cardiometabolic patients as having Total Body Meltdown and recommend a protocol of stabilized ionic minerals (ReMag, ReMyte, Pico Silver); food-based and methylated B’s, and amino acids that are precursors to glutathione production (ReAline); life force and perfect cell enhancers (RnA ReSet Drops and ReStructure). BAM! Lo and Behold that approach works – people feel better and get better and their lives are restored as they support the structure and function of their body.
The article laments that “We know that there’s a big problem out here in our country today, and it’s called Cardiometabolic Disease…Unfortunately, it covers over one-third of the population, and more unfortunately, the older you get (over 60 years of age), the more likely you are to have this metabolic issue that can lead to cardiovascular disease. These components are any 3 of the following: hypertension, impaired glucose and lipid metabolism, excess belly fat, or obesity, and (they can also have) inflammation.” 
What they don’t say is that all of these conditions are associated with various stages of magnesium deficiency. And the older you get, the more drugs you are likely to be taking, which means you are developing more magnesium deficiency every day.
Let me include here an edited excerpt a section from The Magnesium Miracle where I follow the recognition of Syndrome X that became Cardiovascular Metabolic Syndrome AKA Metabolic Syndrome.


Dr. Lawrence Resnick of Cornell University, involved in heart and magnesium research since the early 1980s, calls Syndrome X –  Cardiovascular Metabolic Syndrome (CVMS). Dr. Resnick says it is characterized by a high calcium-to-magnesium ratio. Remember, too much calcium automatically creates a magnesium deficiency.[i]

NOTE: Dr. Resnick passed in 2004 but he was recognized world wide for his work on hypertension and CVMS. His obituary says that “Dr. Resnick broadened our understanding of metabolic disturbances associated with diabetes, obesity, and hypertension.” 

Americans in general have a high calcium-to-magnesium ratio in their diet and consequently in their bodies. Finland, which has the highest incidence of heart attack in middle-aged men in the world, also has a high calcium-to-magnesium ratio in the diet.[ii] The U.S. ratio in this study is said to be 3.5 to 1, Finland’s ratio is 4 to 1.8. Finland’s cheese consumption is third in the world – and cheese is very high in calcium.  

With a dietary emphasis on a high calcium intake without sufficient magnesium, according to magnesium expert Dr. Mildred Seelig, we will soon be faced with a 6:1 ratio in our population. The conventional recommended dietary ratio of calcium to magnesium, 2:1, has been debunked. To reverse Syndrome X, it may be necessary to only use 600 mg per day of calcium from dietary sources and 600 mg of magnesium in supplement form.


According to Dr. Resnick, Syndrome X is caused, not by chronically elevated insulin levels, but by a low level of magnesium ions—because insufficient magnesium is the original cause of insulin resistance.[iii] As stated, insulin opens the cells to glucose only if the cells have sufficient amounts of magnesium, and without magnesium, insulin resistance occurs. Studies clearly show that animals deprived of dietary magnesium develop insulin resistance, and the human population has the same risk.[iv] Some researchers conclude that hypertension and insulin resistance may just be different expressions of deficient levels of cellular magnesium.[v] The various conditions that make up Syndrome X, CVMS, or Metabolic Syndrome, its most recent designation, all have similar origins in magnesium deficiency. But it’s not a designation that many doctors have adopted since they separate all the risk factors and treat each separately with different drugs.

The magnesium deficiency in Syndrome X comes from a combination of our magnesium-deficient diet and the well-documented loss of magnesium in the urine caused by elevated insulin. A vicious cycle creates further magnesium losses, causing more Syndrome X symptoms. In a fifteen-year study of 5,000 young adults, it was found that the more magnesium in the diet or taken as supplements, the lower the likelihood of developing Metabolic Syndrome.[vi]

Note: To my mind, it’s too confusing to have all these different names that mean the same thing: Syndrome X, Insulin Resistance, Cardiovascular Metabolic Syndrome, and Metabolic Syndrome. The reason why none of them are household words or diagnostic criteria is because medicine doesn’t have a drug to treat them. Allopathic medicine wants to label a disease and match it with a drug. Since these conditions are mostly lifestyle, diet and mineral deficiency diseases with no one drug to treat them, they are, for the most part, ignored.

The cornerstone of both prevention and treatment of any of these syndromes is to restore magnesium to normal levels. Unfortunately, for many, the ravages of diabetes, high blood pressure, and high cholesterol have taken their toll, but even then, magnesium taken along with medications can play a beneficial role in controlling and reducing symptoms.[vii] [viii]

The Medscape Case Study went on for whab 7,000 words mostly about the horrors of Cardiometabolic Disease and the many drugs to treat it. They gave lip service to “behavior modification — lifestyle changes, educating patients on diet and weight loss, getting them more   active.” But then they quickly move on to “the angiotensin converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), and statin medications.” But let’s not stop there! “The addition of ezetimibe or progressing to proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors if needed. You’re also going to address the metabolic needs, insulin sensitizers, potentially the use of metformin or pioglitazone are options as well to treat the metabolic disorder.” 
Treating cardiometabolic disease medically has gotten so complex, so toxic, and so ineffective that it is no wonder that doctors and patients are all developing Medical PTSD. I write about the effect on doctors in my blog “The High Rate of Doctor Suicide” which I will share with you here.

Doctors are dissatisfied, patients are dissatisfied and they are both dying because nobody is paying attention to the cause of their discontent. In my Death by Modern Medicine 3rd Edition, I say iatrogenic medicine is causing over a million premature deaths annually. According to Dr. Pamela Wible, doctors are opting out of this mayhem by committing suicide.

I associate Bible with Dr. Wible because she’s pretty much a saint in the way she practices “ideal medical care” and mentors other doctors and clinics to do the same.

I’m feeling quite at home reading Dr. Wible’s “Pet Goats and Pap Smears” because her clinic so much resembles the one I ran from 1979-1992.

When a patient complains to Dr. Wible about a surgeon saying: “This guy didn’t listen, never even looked me in the eyes, didn’t act like he even cared! What’s with all these rich, arrogant doctors these days?”

Dr. Wible explains to him that “Physicians are good people who are victimized. They’re overwhelmed and exhausted. It starts in school with dehumanizing and barbaric animal experiments. Everyone in my medical school class had to kill a dog to graduate! Add the sleepless nights on call and the economic stranglehold. Do you realize med students graduate with over $200,000 in student loans? Then, when they graduate they’re funneled into assembly-line clinics. After all the abuse, doctors are emotionally and spiritually disconnected from themselves and their patients. It’s tragic. No wonder we lose a doctor with each day to suicide and sixty percent of doctors want to quit.”

Dr. Wible went to medical school in the mid 90’s I went in the mid 70’s. Thank goodness I wasn’t required to kill a dog in my training – I would have refused, just like Pamela did. I also refused to give chemotherapy, do abortions on women I’d never even met, and pull the plug on patients. I didn’t stage a sit in or go on strike, I just told the nurses not to call me for any of those procedures. I respected the nursing staff and they respected me, so I somehow escaped with my soul intact.

Direct action was how I handled an incident in the first week of first year medicine. A lecturer used nude female slides to keep his mostly male audience awake. The 33 women out of 100 students (and some men) were shocked. I didn’t know anyone in my class so I immediately went out and bought a Playgirl Magazine and had several nude male slides made and put them in that same lecturer’s slide carousel for his next lecture. With the first nude male slide he grabbed his briefcase and ran from the auditorium to great laughter and hilarity. Overnight all the nude female pictures in anatomy labs and all over campus disappeared.

Dr. Wible is right about the doctors graduating with so much debt that they have to immediately go into assembly line medicine and toe the line so they don’t lose their license. I’m sure the figures are closer to $500,000 owing. I had a couple of doctors come to work with me but they all left because they couldn’t make enough money in a practice consisting of extremely complex patients who required 30-60 minute appointments.

The work that Dr. Wible is doing is wonderful and she has developed a following of doctors and clinics. But she has set herself a near-impossible task if, you the public, don’t do your part. To change medicine at this point is like trying to clean up a dirty closet in a very large house. The closet is the inhumane assembly-line of current allopathic health care with all the drugs and surgery and technology that money can buy. The whole house offers the limitless possibilities of offering people ethical and humane alternatives and it’s the whole house that we want to occupy.

Dr. Wible has a tremendous amount of commonsense, and as she told me in private communication, she routinely weans patients off high blood pressure meds and cholesterol meds. Her goal is to remove patients from allopathic drugs and rely on nutrition and lifestyle changes whenever possible.

What is the end stage of cardiometabolic disease? Heart Failure! Here is my take on heart failure that I wrote in a blog called “Hearts Don’t Fail Doctors Fail.”

There appears to be an epidemic of heart failure. But, in my opinion, hearts aren’t failing; it’s doctors who are failing to treat heart disease properly. The problem begins with the name doctors use for this disease. They don’t seem to realize that declaring that a patient’s heart is failing sets the patient up for just that…failure!

A study in the July 2013 issue of Circulation: Cardiovascular Quality and Outcomes comments on the high hospital readmission rate of heart failure patients. Researchers report that: “A million people are hospitalized with heart failure each year, and about 250 000 will be back in the hospital within a month…If we could keep even 2% of them from coming back to the hospital, that could equal a saving of more than $100 million a year.”

Note: Researchers admitted that they found this study very discouraging and subsequent reports showed that they could not come up with a medical solution. The only way they could influence this trend was to financially penalize hospitals that had high rates of readmission. 

Heart failure is diagnosed by a combination of cardiac catheterization, CT scan or MRI and ultrasound to measure the ejection fraction of the heart. The ejection fraction depends on the strength of the heart muscle, specifically the ventricles, to pump blood   through the vast network of arteries and capillaries in the body. Did you know that the largest amount of magnesium in the body is found in the heart ventricles? Did you know that muscle cells depend on the proper balance of magnesium and calcium for proper function? If the ventricles are not ejecting blood properly my first concern would be for magnesium.

Instead doctors have a standardized treatment of 6 drugs – often sold together in blister packs so you don’t miss a dose. The drugs are for blood pressure, cholesterol, fluid retention and to push the heart to beat stronger. Rarely in the heart failure literature is there any mention of magnesium, yet all these drugs deplete your body of magnesium.

Even worse, people tell me they are afraid to take magnesium and their doctors warn them not to take magnesium in case it interferes with their medication! How has it come to the point where patients are being warned not to take something that’s as important as air, food and water because it will lessen your need for drugs? What has occurred to cause doctors to distrust necessary nutrients and prescribe drugs for life instead of short term while the body heals itself?

I’ve said this many times, especially in my Death by Modern Medicine: Seeking Safe Solutions book. Doctors don’t learn anything about using vitamins and minerals clinically in medical school or in hospital training. Even though it’s now a fact that magnesium is responsible for the proper functioning of 700-800 enzyme systems in the body (more than the 325 I’ve reported in the past), doctors have turned a blind eye to the epidemic magnesium deficiency.

If your doctor won’t test you for it, get your own Magnesium RBC test (Request A Test) for $49.00 and aim for an optimum level of 6.0-6.5mg/dL.

My focus is to always support the structure and function of the whole body. I don’t just focus on cardiometabilic disease, because medical PTSD, drug toxicities, and weakening of the adrenals, thyroid, and every other body part can occur in Total Body Meltdown. And I do not recommend going off your medications unless and until your body responds and you no longer require them. Even the most complicated scenario is amenable to our stabilized ionic forms of minerals: ReMag, ReMyte, Pico Silver and our highly absorbed food-based and methylated B Vitamin: ReAline that also contains sulfur-based amino acids, one of which is a precursor to glutathione. The most unique, innovative and life-changing nutrient is our RnA ReSet Drops. You must see our webinar on youtube called RnA ReSet Drops Webinar where I describe the life force that is imparted to the soil by the waste product of spent barley sprouts from making our RnA ReSet Drops. Our ReStructure protein powder actually contains some RnA ReSet powder to start you on your wellness journey.


[i] Resnick LM, “Cellular ions in hypertension, insulin resistance, obesity, and diabetes: a unifying theme.” J Am Soc Nephrol, vol. 3 (4 suppl.), pp. 578–585, 1992.

[ii] Karppanen H, Neuvonen PJ, “Ischaemic heart-disease and soil magnesium in Finland: water hardness and magnesium in heart muscle.” The Lancet, Dec. 15, 1973

[iii] Resnick LM, “Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of Syndrome X.” Am J Hypertens, vol. 6, no. 5, pt. 1, pp. 413–417, 1993.

[iv] Resnick LM, “The cellular ionic basis of hypertension and allied clinical conditions.” Prog Cardiovasc Dis, vol. 42, pp. 1–22, 1999.

[v] Resnick LM et al., “Hypertension and peripheral insulin resistance. Possible mediating role of intracellular free magnesium.” Am J Hypertens, vol. 3, no. 5, pt. 1, pp. 373–379, 1990.   

[vi] He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L, Jacobs DR, Savage PJ, “Magnesium intake and incidence of metabolic syndrome among young adults.” Circulation, vol. 113, no. 13, pp. 1675–1682, 2006.

[vii] Paolisso G et al., “Low fasting and insulin-mediated intracellular magnesium accumulation in hypertensive patients with left ventricular hypertrophy; role of insulin resistance.” Hypertens, vol. 9, pp. 199–203, 1995.

[viii] Nadler JL et al., “Magnesium deficiency produces insulin resistance and increased thromboxane synthesis.” Hypertension, vol. 21, no. 6, pt. 2, pp. 1024–1029, 1993.

Carolyn Dean MD ND

The Doctor of the Future®

RESOURCES: Along the borders and in the links of my web site you can find my books, writings, and my call-in radio show. Email your questions to:

Want more health info like this?

Subscribe to receive FREE health tips from Dr. Carolyn Dean. We won't spam you or sell your information.