|Actually the practice of surgery on infants in the womb is commonplace and most often successful. And I think that has spurred on giving meds and doing gene therapy in the womb.|
|An article in Chemical & Engineering News “Fetal Gene Therapy Could Treat Diseases in the Womb” caught my attention. “Emboldened by recent success stories of human gene therapy trials in children and infants, researchers are now pushing to treat diseases before birth. Some scientists are excited by the idea of using fetal gene therapy to fix genetic conditions that can’t be treated after birth, but others raise questions about the technique’s feasibility and practicality in humans.”|
|I’d also worry about whether gene therapy is even viable. It’s in the exciting stages of novelty and gets LOTS of funding but does it even work? In 2005 when I wrote Death by Modern Medicine, I said that drug companies and modern medicine are pursuing gene therapy: |
“…to develop new lines of revenue as more and more drugs are recalled because of the high rate of side effects. When scientists on the Human Genome Project claimed that identifying all the genes in the body would allow us to have complete control over our bodies, everybody believed this Star Trek fantasy.
In 1990, Dr. French Anderson, Director of Gene Therapy at the University of Southern California Medical School, performed the first human gene therapy experiment. Unfortunately, the procedure, on a young four-year old girl was successful. Unfortunate, because the first experiment was such a huge success, it created a very optimistic view of the procedure. By 1996, according to Dr. Anderson, gene experiments in over 3,000 participants mostly ended in tragedy.
|Back to the article on diabetes that quotes a study in 2004 that followed almost 700 kids with youth-onset type 2 diabetes who were randomized to receive one of three treatments – each one of them included at least one medication – and no magnesium. The three treatments were: metformin, metformin plus rosiglitazone, or metformin plus lifestyle intervention. |
|Magnesium deficiency is a sign of diabetes in all the medical books but was ignored. The Keto diet that restricts carbs and can reverse diabetes was not considered. Instead, according to the article, “these kids are continuing to accumulate very high rates of comorbidities and complications… accelerating rates of cardiovascular disease, renal disease, eye disease, and nerve disease, as well as very high rates of pregnancy complications for both the mother and the offspring.” |
|Our adult customers, who are an average age of 60, come to us with Total Body Meltdown. They list diabetes, cardiovascular disease, renal disease, eye symptoms, nerve symptoms, etc., which are all related to magnesium deficiency. Now children are developing these conditions before their teens – they might not even make it into adulthood!|
|The American Diabetes Association steps into the fray with guidelines that are all about aggressively treating kids as early as possible with a cocktail of drugs. The article even admonishes pediatricians who “are hesitant to add medications or to expose young kids to medications that we feel they maybe don’t need.” |
|Instead, they insist that “these kids need a more aggressive intervention than is recommended for older people because they have a more serious trajectory and will be living with these cardiovascular risks for a very long time.” BAM! |
|To me that sounds like the death knell for the next generation of victims of modern medicine. Taking more drugs earlier is only going to make them more magnesium-deficient earlier and cause earlier death. But Big Medicine pushed by Big Pharma to only use drug therapies will never embrace the necessity of enhancing health at the cellular level using well-absorbed nutrients that I talk about all day and every day!|
|Children are affected on every level with magnesium deficiency, just like adults. Here’s what I write about magnesium-deficient kids who suffer with anxiety and mood disorders in my Magnesium Miracle book. |
It’s not just adults who can get anxious because of a magnesium-deficient lifestyle. Our children are also susceptible when their favorite foods are magnesium-deficient hot dogs, pizza, and soda. The stress in their lives—from peer pressure, bullying, academic and athletic performance pressures, worries about body image, the changes and hormonal fluctuations of puberty, exposure to negative events and violence through the media—all contribute to magnesium deficiency. As noted above, even burning off steam by playing in a band can be a risk factor.
Children are underdiagnosed when it comes to magnesium deficiency, but they develop magnesium deficiency for the same reasons as adults. Attention deficit hyperactivity disorder (ADHD), autism, juvenile delinquency, and childhood depression are associated with magnesium deficiency, and some say these conditions can be caused by it.[i]
Dr. Sharna Olfman, a professor of clinical and developmental psychology, issues the following warning in her book No Child Left Different:[ii]
“The number of American children being diagnosed with psychiatric illnesses has soared over the past decade and a half. The National Institute of Mental Health (NIMH) estimates that today, one in ten children and adolescents in the United States ‘suffers from mental illness severe enough to result in significant functional impairment.’ During this same time period, psychotropic drugs have become the treatment of first choice rather than the treatment of last resort. Recent years have witnessed a threefold increase in the use of psychotropic medication among patients under twenty years of age, and prescriptions for preschoolers have been skyrocketing. Over 10 million children and adolescents are currently on antidepressants, and about 5 million children are taking stimulant medications such as Ritalin.”
In 2005, Columbia University initiated a program called Teen Screen throughout forty states, which screened teens and children for mental health problems. Unfortunately, such screening usually leads to the prescribing of more drugs. Instead of reaching for Ritalin or Prozac for kids, consider whether they’re getting enough magnesium first. If these children were simply taken off sugar and put on magnesium, we would have much happier children and thus far fewer side effects from powerful drugs.
Dr. Leo Galland, author of Superimmunity for Kids, speculates that hyperactive children need extra magnesium due to their constantly high adrenaline levels. Dr. Galland recommends 6 mg per pound of weight per day (for example, 240 mg for a 40-lb child). I agree with this recommendation because it is more than twice the 6 mg/kg RDA of magnesium.
For children, I recommend the non-laxative picometer magnesium, ReMag, ½ tsp twice a day hidden in juice or a smoothie. You can also put it in a spray bottle to use transdermally or you can use ReMag Lotion.
|I also recommend that kids take B Vitamins. The writer of a Medscape article called “High Rates of B Vitamin Deficiency in Teens With Mental Illness” agrees. According to a recent study, children and adolescents with psychiatric disorders have low levels of vitamins B9 (folate) and B12. The concern of the researchers is that such deficiencies may affect neurodevelopment.|
|A hospital clinic in Barcelona, Spain treated 780 young people with psychiatric disorders over a 3-year period. They found that about 40% of patients were deficient in vitamin B9, and approximately 20% were deficient in vitamin B12. Just more than 10% were deficient in both vitamins. Patients with depressive symptoms were more likely than others to be deficient in vitamin B12.|
|The findings were presented at the European Psychiatric Association (EPA) 2019 Congress byAnmella Diaz, who told the conference delegates that his findings are “very important because they highlight a problem” that has been neglected in this patient population. He noted that the proportion of adolescents who are deficient in vitamin B9 and B12 is double that of children.|
|Vitamin B9 and B12 are important because they are both involved in glutathione and myelination pathways and involved in neuroplasticity and the preservation of neuronal integrity. The paper mentions that deficiencies in these two vitamins lead to hyperhomocysteinemia, which has been linked to neurovascular and neurodegenerative disorders and psychiatric disorders, including schizophrenia and affective disorders, as well as cognitive impairment.|
|Of course they leave out the importance of magnesium in preventing homocysteinemia. I write about this in The Magnesium Miracle with a focus on heart health but too much homocysteine can also affect the brain. So when you hear about the heart effects from elevated homocysteine, just substitute brain effects.|
|When protein breaks down, it produces homocysteine. The major enzymes involved in breaking down and getting rid of homocysteine are magnesium-dependent. An optimum level of homocysteine is between 10-12 µmol/L. When homocysteine is elevated in the cells, it depletes cellular magnesium because magnesium is needed to break it down. Twenty to 40 percent of the general population have high levels of homocysteine in the blood. Individuals with high levels have almost four times the risk of suffering a heart attack compared to people with normal levels.[iii]|
|Hyperhomocysteinemia is high on the list of risk factors for heart disease and serves as an even stronger marker than high cholesterol for heart disease and blood clotting disorders.[iv] [v] However, it is not on a standard blood test panel for heart disease – likely because there is no drug treatment to lower homocysteine.|
|I say the more relevant marker may be low magnesium since the major enzymes involved in homocysteine metabolism are magnesium-dependent.[vi] Dr. McCully blames too much protein in the diet for hyperhomocysteinemia. However, when magnesium, vitamin B6, vitamin B12, and folate are deficient, the body is not able to properly digest dietary protein. Magnesium and the B vitamins were readily available in the typical diet a hundred years ago; now that they are absent, homocysteine becomes elevated resulting in heart disease.|
|When these metabolic nutrients are reintroduced through diet and supplements, the high homocysteine levels are reversed and the symptoms of heart disease diminish. Ongoing research confirms that B6, B12, and folate together with magnesium are necessary to prevent blood vessel damage induced by high levels of homocysteine in the blood.[vii] It is clear that the successful treatment of hyperhomocysteinemia relies on dietary changes that include B vitamins and magnesium.[viii] [ix] [x]|
|However, magnesium is often left out of the prescription for hyperhomocysteine in favor of the B vitamins—a common but serious error on the part of conventional medicine. The most effective B vitamins are in the methylated form. The source I recommend is ReAline, which has 4 methylated B’s and also contains taurine – another nutrient that helps metabolize homocysteine. And it contains methionine, the precursor to glutathione that also requires B6 and B12 in its production.|
|Researchers have found that high homocysteine is also a marker for all causes of mortality, which underscores that a deficiency in essential nutrients has far-reaching effects on the body beyond heart disease.[xi]|
|Back to the Medscape article, which says that during childhood and adolescence, the brain undergoes synaptic pruning and reconstruction and the development of learning and memory circuits and executive functions, making it particularly vulnerable to B vitamin deficiency. We also know that magnesium is responsible for a high degree of brain plasticity and adaptability.|
|The recommendation by Dr. Diaz is to supplement with the deficient vitamins. Unfortunately there was no discussion about dosage of the use of synthetic B vitamins versus methylated and/or food-based supplements. Of course with no discernable education about nutrients in medical school most doctors think that the synthetic chemical formula of vitamin is equivalent to the natural form – which just makes no sense.|
|Unfortunately, the recommendation of many studies to use dietary supplements comes at the same time that many doctors are telling their patients that “Vitamins and Supplements Are a Waste of Money.” This July 2019 commentary in Medscape can’t help but influence doctors who know nothing about dietary supplements and take the writer’s word as gospel. |
|As these types of articles often do, they focus on the amount of money being made by the supplement industry as if they are concerned about their patients’ pocketbooks. Apparently the industry has reached the 30 billion dollar mark and the writer says “most of that money is being wasted.” |
|I may not agree that dietary supplements, especially synthetics are universally effective, but at least they are not toxic. And the bonus is that they may keep people away from unnecessary medications that are infinitely more toxic and dangerous. However the way they study dietary supplements is fundamentally flawed.|
|The writer comments on a review in the Annals of Internal Medicine, supposedly a comprehensive report of randomized trials of vitamins and supplements that examines their effects on cardiovascular disease and overall mortality.|
|The study Included only Randomized Trials and the writer thought this was a great choice. Why? A randomized study assigns participants into an experimental group or a control group. The experimental group is given the nutrient and the control group is not. All other variables are controlled. That’s it. Even though every nutrient in the body works together with every other nutrient and even though nothing works in a vacuum, scientific research demands a vacuum. And thus scientific research will never be able to properly study nutrients. But they think they can and they say they can and they will draw false conclusions that actually hurt people because they are so wrong.|
| The writer disses Observational Studies of vitamin and supplement usage saying that “they are plagued by what’s known as ‘healthy user bias’: Individuals who choose to take vitamins often engage in other healthful behaviors. Time and again, vitamins that looked promising in observational studies failed in large randomized trials.” He says that this paper puts “all of the best data surrounding vitamins and supplements in one place,” which allows him to say the following: “There is no high-quality evidence that any vitamin or supplement has a beneficial effect on overall mortality.” |
|In a very derogatory, demeaning, and irritating tone the writer says that “The analysis included studies of 24 different interventions…comprising 277 randomized trials and nearly a million patients. And, basically, bupkis.” |
|LORD SUFFERIN’ CATS! It’s because you can’t study individual nutrients that you don’t get results. And, nobody is putting up the millions of dollars to do the so-called scientific studies. I’ve always said, just give me a few million and I’ll put a few hundred people on my products and show you how they get their health back. Oh, Wait! That’s what we are doing already – and getting amazing testimonials from our customers that we can’t share with you on our websites because the FDA doesn’t want the public to think that nutrients are better than drugs. |
|The next ridiculous thing that this writer said was that “The only intervention that had even moderate-quality evidence for protection against all-cause mortality was reducing salt intake, which, frankly, doesn’t sound like a vitamin or supplement to me.” This is another load of crap when our customers can attest to the fact that when taking sea salt in their drinking water they immediately feel better as the minerals follow water into the cells and vice versa. Minerals plus hydration = better health.|
|conclusion the writer pontificates “…let’s remember that vitamins were, by and large, identified via their deficiency syndromes. We know that vitamin C is vital for life because without it, people get scurvy. But there has never been much rationale as to why a super-intake of any of these chemicals would give super-benefits to health.” This is the position of the NIH – that they are only interested in nutrients to the extent that they prevent deficiency diseases – thus the RDA of vitamin C is only 60mg to prevent scurvy. I was told years ago at an NIH conference on nutrients that the NIH has no interest in studying nutrients to treat or prevent disease. |
|That was also the position of the nefarious Codex Alimentarius that tried to regulate dietary supplement across world wide borders. They wanted to standardize nutrients to the very lowest dosage of synthetic supplements THAT WOULDN’T INTERFERE WITH DRUGS. Hopefully President Trump has put a stop to that abuse.|
|In one last swipe at our intelligence, the writer of “Vitamins and Supplements Are a Waste of Money” opines “It remains possible that vitamins and supplements might improve subjective quality of life. But you know what else improves quality of life? Money. And based on this study, you might want to save yours when you’re walking down the vitamin aisle.” |
|The damage that this article will cause cannot be ignored. Doctors will read it and with renewed fervor against anything that they didn’t learn in medical school (which includes nutrients) they will repeat this nonsense to every patient they see in their office. Most patients will believe their doctor because she/he is the “authority” and they won’t even bother looking further.|
|If they do look further they may have the good fortune to come across my website and my commonsense words and make their own decision about who to believe.|
Carolyn Dean MD ND
The Doctor of the Future®
RESOURCES: Along the borders and in the links of my web site you can find my books, writings, and my call-in radio show. Email your questions to: firstname.lastname@example.org.
[i] Starobrat-Hermelin B, Kozielec T, “The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test.” Magnes Res, vol. 10, no. 2, pp. 149–156, 1997.
[ii] Olfman, S. No Child Left Different, Praeger, Westport, CT, 2006, p. 1.
[iii] Eikelboom JW et al., “Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence.” Ann Intern Med, Vol. 131, No. 5, pp. 363–375, 1999.
[iv] Boushey CJ et al., “A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.” JAMA, vol. 274, no. 13, pp. 1049–1057, 1995.
[vi] Altura B, Altura B, “Magnesium: the forgotten mineral in cardiovascular health and disease.” A Gem Lecture at SUNY Downstate. Alumni Today, pp. 11–22, spring 2001.
[vii] Li W et al., “Extracellular magnesium regulates effects of vitamin B6, B12 and folate on homocysteinemia-induced depletion of intracellular free magnesium ions in canine cerebral vascular smooth muscle cells: possible relationship to [Ca2+]i, atherogenesis and stroke.” Neurosci Lett, vol. 274, no. 2, pp. 83–86, 1999.
[viii] Shamsuddin AM, “Inositol phosphates have novel anti-cancer function.” Journal of Nutrition, vol. 125 (suppl.), pp. 725S–732S, Review 1995.
[ix] Rowley KG et al., “Improvements in circulating cholesterol, antioxidants, and homocysteine after dietary intervention in an Australian Aboriginal community.” Am J Clin Nutr, vol. 74, no. 4, pp. 442–448, 2001.
[x] Tice JA et al., “Cost-effectiveness of vitamin therapy to lower plasma homocysteine levels for the prevention of coronary heart disease: effect of grain fortification and beyond.” JAMA, vol. 286, no. 8, pp. 936–943, 2001.