Marketing Migraines Without Magnesium - Dr. Carolyn Dean MD ND

Marketing Migraines Without Magnesium

July 28, 2019

Drug companies spend billions doing market research on their drugs and here is an example of how they go about it. A survey was conducted to determine “Patient Preferences for Preventive Migraine Treatments and published in the journal Headache as if it were an actual scientific study.

Its objective was “To understand treatment preferences of people with migraine and the relative importance of improvements in efficacy and avoiding adverse events (AEs), such as cognition problems or weight gain.” The researchers were investigating the “poor adherence and tolerability” of preventive migraine drugs and studying the unmet need for effective migraine-specific preventive treatments with fewer AEs.” Yes, that’s right Big Pharma, patients do want “drugs” that work and don’t hurt! Who wouldn’t? But that’s not what this survey was about. It was trying to determine how much and how many side effects would patients put up with to get a little relief and what price would they pay!

The researchers lamented that at least 80% of treated subjects discontinue their preventive migraine medicine within a year, likely due to side effects or lack of efficacy. The people surveyed suffered an average of 16 headache days per month, and 75% revealed that migraine limited their physical activities all or most of the time. In spite of all that suffering only 30% of respondents had taken a prescription medicine to prevent migraine in the last 6 months, and 14% indicated that they had never taken a prescription medication to prevent migraine.

That meant that two thirds of the migraine population is not buying drugs and the drug companies want to capture that market.

The article droned on for 5,500 words and determined that the survey “respondents had a significant willingness to pay for medicines with higher efficacy and less-severe AEs.” 

Before I launch into the whole can of worms about Biologic Medicine here’s what can happen if you treat the underlying cause of most migraine headaches – magnesium deficiency – with a non laxative magnesium – ReMag. 

Hello from Australia!

I started taking ReMag and ReMyte about a month ago for heart palpitations, my underactive thyroid and headaches/migraines.

I’m up to 3 teaspoons a day of ReMag and 1 teaspoon a day of ReMyte (I’m aiming for 2 a day)

I’ve already seen a difference in my headaches. They are much less frequent and, if I do get one, it resolves in a number of hours as opposed to 4-5 days previously.

Biologic Medicine

The “scientific” survey had an ulterior motive. Biologic Drugs are much more expensive than the more common chemical ones. The sole purpose of this survey was trying to justify the cost of Biologic Medicine for migraine prevention under the guise of wanting to help suffering patients prevent migraine headaches.

Let me give you and overview of biologic medicine by describing a migraine drug called Aimovig. It was approved by the FDA in 2018. It’s a CGRP-inhibitor, biologic medicine produced by altering the DNA inside a living cell rather than being chemically synthesized. It’s a monoclonal antibody that targets a protein in the brain and nervous system called calcitonin gene-related peptide (CGRP) that blocks migraine pain.

During a migraine attack, it’s believed that CGRP is released from trigeminal nerve fibers in the head and face. CGRP causes inflammation and transmits pain signals to the brain. It also dilates the blood vessels outside and inside the skull, which is believed to be another trigger for migraine pain. Aimovig works by blocking the docking sites of CGRP receptors to stop inflammation and pain.

Note the wording “it’s believed that CGRP is released from trigeminal nerve fibers.” Which means they don’t really know for sure and they are also not saying how many other places in the body have active CGRP receptors. 

It was easy to find more information on CGRP, which, as it turns out, is NOT just produced by the trigeminal nerve as the study implies. It is produced in both peripheral and central nerve cells. It is a potent vasodilator and transmitter of pain throughout the body. While some people may think all pain should be banished, we depend on pain stimuli as a warning signal. And vasodilation can be a very necessary function for blood pressure control and circulation. Drug researchers may want you to think that a CGRP blocker is only going to block the trigeminal nerve but commonsense will tell you that is a hopelessly naïve conclusion.

Here’s another important function of CGRP that seems to be overlooked by the scientists trying to block its function. CGRP contributes to the regeneration of nervous tissue after injury. Also, CGRP plays a role in cardiovascular homeostasis and nociception. Think about that for just one second. Wouldn’t you want to know if you have chest pain so you can either stop your exertion or go to the hospital to find out if you are having a heart attack? Wouldn’t you want to have all the nervous tissue regeneration that your body could muster if you had an injury? Would you want your cardiovascular system to be in balance? CGRP also plays a role in the respiratory, endocrine, gastrointestinal, and immune systems. Will being injected with a CGRP blocker once a month at a cost of $575 per shot keep you from feeling these body functions? Yes! 

Note: Biologics have to be injected, which helps explain their extreme cost.

A $575 injection once a month ($6,900 per year) is the future of migraine prevention! And as this study “proves” people are willing to pay the price! Lord Sufferin’ Cats!! Oh, you can also add on the cost of a visit to your neurologist for the injection. That’s another $300 a visit or $3,600 for a total of $10,000 for the possibility of preventing migraines. Perhaps it would be worth it, but only to people who could afford it, if it worked. But does it work – every time without fail or exception? 

Is Aimovig a cure for migraine? The answer is a resounding – No. Here are the results of several clinical trials. “For people with episodic migraine, between 40 percent and 50 percent of those who took Aimovig for six months cut their number of migraine days by at least half.” So it only helps less than half of patients half of the time. It also has a long list of side effects, some of which can be fatal. Saying it’s biologic implies to the patient that it’s “natural” but that’s far from the truth.

Here are even more nails on the coffin of this drug. It’s a calcitonin gene-related peptide (CGRP). What does calcitonin do? It acts to reduce the amount of calcium in the blood – because too much calcium in the blood causes blood clots and too much calcium in the soft tissues cause calcification. One of the triggers of migraines is said to be tiny blood clots that get hung up on small arteries lined with calcium in the face and head!

What substance helps dissolve calcium in the blood and soft tissues (including arteries) and acts as a natural calcium channel blocker? MAGNESIUM – that’s what! 

Magnesium doesn’t function like a drug or abnormally block anything that it shouldn’t. It just does what it’s supposed to do in 80% of known metabolic functions of the body utilizing 1,000 enzyme processes. But you have to have enough magnesium to do the job, which means using a non-laxative magnesium like ReMag.  

Let me share with you a rant about Biologic Drugs that I did on my June 24, 2019 Radio Show. 

I became more aware of the pervasiveness of these drugs when I did my 50 hours of continuing medical education credits for my CA license in early 2019. I don’t practice in California but I retain my license to force myself to do these CME credits to keep up with medical trends.

Well the trend is that Modern Medicine has given up on chronic disease caused by nutrient deficiencies and yeast overgrowth because there are no chemical drugs to treat those conditions and it’s now focusing on autoimmune disease and cancer, which have, in part been created by modern medicine because they don’t treat nutrient deficiency and yeast overgrowth with drugs! What a hopeless bind medicine has created for itself and for its patients!

I’ve said for decades that auto immune disease is caused by yeast overgrowth and magnesium deficiency, but we all know those triggers will never be addressed by modern medicine. Cancer has the added failure of modern medicine to look at the conflict basis of serious diseases that I explore with Total Biology and German New Medicine.

I think the terms Biologic Drugs and Biologic Medicine were invented to make people feel warm and fuzzy and think it’s somehow “natural”. Critics say these drugs are Cutting Edge, Complex, and Costly compared to chemically-derived drugs.

I repeat, these drugs are being given to the most complex patients suffering serious symptoms in a climate of magnesium and nutrient deficiencies that make all the side effects of the Biologic Drugs much worse.

Most biologics are very large, complex mixtures of molecules that can cause serious allergic reactions. The function of the immune system is to ramp up when faced with a foreign chemical. Also, any biologics are produced using recombinant DNA technology – which implies that rogue DNA is released in the body. The ramping up of the immune system to try to defend against these biologics and rogue DNA may be all that is happening when these drugs are administered by IV or IM injections. The defensive reaction is then misinterpreted as the drug having a positive effect! 

Dr. Mildred Seelig, a magnesium expert told me on the phone one day that when she first got out of medical school she worked in a pharmaceutical company to help assess what happens to nutrients in the body when drugs are taken. She found an interesting pattern. Drugs cause magnesium to be released from storage causing blood levels to rise. When magnesium is elevated in the blood it can be put to use by the 1,000 enzymes systems that it activates. Boom! You feel better. Boom! You think it’s the drug! And then Boom! After a month or two you don’t feel so good because stored magnesium is used up and you start experiencing “drug side effects” which often mimic magnesium deficiency symptoms. Is that why most drug studies only last a month or two to avoid the timing of side effects? Dr. Seelig reported these findings to her superiors and nobody seemed to pay attention and she finally left Big Pharma and devoted her life to promoting magnesium and magnesium research. 

The downside of that story is that she died of heart failure, I think because she was only taking magnesium oxide!! Other prominent researchers have told me that they also take magnesium oxide but only in small amounts because of the laxative effect. They know the importance of magnesium yet they never stop to think there could be a non-laxative form.

Something just hit me like a ton of bricks! I’m always complaining that there is no good blood test for magnesium and that it’s not even on the electrolyte panel and it’s completely ignored by medicine. What if the drug companies, knowing that magnesium is the hidden factor in the initial response to drugs, intentionally ignore magnesium. I’ll leave that thought with you as I continue to puzzle out the vast ignorance of Big Pharma and Big Medicine about such an important mineral.

Back to Biologic Drugs. I’ve edited the following words from MedicineNet

  • They are a product produced from living organisms or contains components of living organisms.
  • They include a wide variety of products derived from human, animal, or microorganisms by using biotechnology.
  • They include vaccines, blood, blood components, cells, allergens, genes, tissues, and recombinant proteins.
  • They may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.
  • They are sometimes referred to as biologic response modifiers because they change the manner of operation of natural biologic intracellular and cellular actions.

They are said to be the most advanced therapies available treating numerous conditions. Some biologic drugs treat autoimmune diseases. They have revolutionized cancer treatment, delayed or reversed the course of immune related conditions, changed the lives of people with rare diseases, and have offered hope for many patients who previously had no effective treatment options for their condition. So, biologic drugs are taking on the worst of the worst diseases and conditions.

Here are some examples of medical uses for biologic drugs: Various cancers, RA, Ankylosing spondylitis, Crohn’s disease, ulcerative colitis, psoriasis, diabetes, multiple sclerosis, heart attack, Lupus, Macular degeneration, diabetic retinopathy, prevent pneumonia, anemia, chronic migraine, Hepatitis B, Hemophilia, RSV prophylaxis, HPV, Varicella vaccine, growth hormone deficiency, Osteoporosis , allergic asthma, chronic urticarial, infertility prevention meningococcal disease, cystic fibrosis, paroxysmal nocturnal hemoglobinuria. 

What are the side effects of biologics?

  1. Allergic hypersensitivity reactions.
  2. Immune system suppression to treat autoimmune disorders can increase the risk of infections. This suppression is serious enough to reactivate Hepatitis B and Tuberculosis.
  3. Injection site reactions if given IM.
  4. Infusion reactions if given in IV drugs

A main side effect of biologic medications is developing a serious infection. The wording chosen for this section is deceptive, they say that “Most likely, these infections are not because of the medications themselves, however, biologic medications change the way your immune works.” Well the medications suppress the immune system and affect your natural ability to fight off an infection. They tell you to let your doctor know if you get any kind of an infection so you can be prescribed another drug – an antibiotic. Now, I’ve always said that autoimmune disease has a yeast overgrowth component. So, as soon as you take that antibiotic you are growing more yeast and the yeast toxins are irritating your immune system and causing more autoimmune symptoms. 

Common side effects of biologic drugs include: chills, weakness diarrhea, nausea, vomiting, rash itching high blood sugar, cough, constipation, SOB, edema, headache fever, muscle aches and pain, decreased appetite, increased TGL, insomnia, abdominal pain, back pain, dizziness. Less common side effects include: central nervous system disorders, cardiac issues, and Lupus-like syndrome. Serious side effects of biologic drugs include: Low blood pressure, anaphylaxis, serious infections, cancer, serum sickness, autoimmune thyroiditis, arterial and venous blood clots, congestive heart failure, bleeding, interstitial lung disease, hepatitis, increased antibodies, enterocolitis, GI perforation, mucositis, stomatitis, anemia, reduced WBCs, hypothyroidism.

As noted above, biologic drugs are administered by injection or infusion because they are proteins that are quickly digested and inactivated if given by mouth.Duh, that’s right, when foreign proteins come into the body the body’s natural first reaction is to get rid of them because they are toxic and can set up serious antigen antibody reactions. So if they are taken by mouth, Boom, the body immediately inactivates them. Maybe it would mean a bit of a fever or headache as that fight goes on. But giving them IM or IV circumvents the first part of the immune system and lets them take hold. Or, perhaps the only people these drugs seem to work on are ones whose immune systems are already beaten down and they can’t fight back. 

Note: I never tell people to stop their medications. If you do use biologic drugs, use them along with all the Completement formulas so that the body can start building new perfect cells. The drugs will not go after new perfect cells but target the unhealthy cells you don’t want anyway. This could be a big breakthrough in medicine. However, I’m also saying that people on the Completement Formulas may not have to go to biologic drugs in the first place.

It’s obvious that Big Pharma has NO intention of investigating magnesium as a migraine preventive, even though it does work and it has no side effects and it is not expensive! Instead they will keep making more and more expensive drugs with more and more side effects. So, it’s up to you to use ReMag at a cost hundreds of times less than Aimovig and talk about ReMag to your migraine-suffering friends to keep them from needlessly suffering twice – once with migraines and then with migraine drug side effects.

Today’s Wellness Tip From the Future…with Dr. Carolyn Dean

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Carolyn Dean MD ND

The Doctor of the Future®

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