PPIs Burn Magnesium, But Who Cares!! - Dr. Carolyn Dean MD ND

PPIs Burn Magnesium, But Who Cares!!

August 7, 2019

In a very patronizing, condescending tone, Medscape advises patients “PPIs Just Stop Worrying” because “PPIs Appear Largely Safe in Multiyear Trial.” Of course, if you are not in the “Largely” group you may suffer a long list of side effects, including magnesium deficiency. Since magnesium is responsible for 80% of known metabolic functions and 1,000 enzyme   processes, you stand to lose a lot when your magnesium becomes depleted. Proton pump inhibitors are the most widely prescribed drug on the planet but doctors are afraid that patients are not taking enough of them.

I’ve noticed that doctors are getting more and more impatient with their patients. I see an obvious patronizing, frustrated, intolerant tone in many Medscape articles where doctors don’t want to be questioned about drug use, drug side effects, or drug effectiveness. They just want patients to take their meds even to the point of asking for drug tests to prove compliance.

In 2014 I wrote a blog called “Drug Noncompliance BS” in which I exposed this trend. Here’s the gist of that post:

A couple of horrendously long Medscape articles really got my blood boiling this morning. One is called “An Epidemic of Noncompliance” the other “Can We Get Patients To Be More Compliant?” The writers said that doctors are “baffled by how many patients, particularly those with chronic conditions, don’t take their medications as prescribed – if at all. Here are the noncompliance stats:

· In the U.S, 3.8 Billion prescriptions are written each year; 50% are taken incorrectly or not at all.

· In a 1,000-patient survey, 75% said they didn’t take their meds as directed.

· In a 75,000-patient survey, 30% failed to fill a new prescription. New scripts for high BP, diabetes and high cholesterol were not filled 20-22% of the time.

· In a 8,400-patient survey, only 1 in 3 were taking their high BP and high cholesterol drugs after 6 months.

· In a 240,000-patient study, 30% were not taking their antidepressant meds after 6 months.

Then attempting to ‘baffle with bullshit,’ the article hammers at the same old tune that patients who don’t take their meds risk hospitalization and premature death. I’m sure they haven’t read my Death by Modern Medicine book. In the 3rd edition, the stats of   drug side effects and deaths are even higher. Ten years ago it was ¾ of a million, now, over 1 Million people die prematurely per year due to modern medicine interventions.

But it struck me that noncompliance is the way medicine is going to explain away iatrogenic medicine. They are saying that you get sick and die because most of you are noncompliant anyway! Wow! Now there’s a Machiavellian twist.

Why are doctors so blind and don’t realize people don’t want to take meds that make them sicker, not better? After all, if their drugs worked, people would be happy to take them! One reason they are so blind is that the allopathic medical industry does not believe in drug side effects. In the articles they say one of the reasons for noncompliance is the “perceived side effects of drugs” by patients!

A person suffering a tendon rupture from the fluoride antibiotic, Cipro, does not have a “perceived side effect” that person could be crippled for life.

Here is a case history from a customer. “We took my mother in for her checkup and told her doctor we wanted to try and get her off some medications, at the very least reduce where possible. We explained that we weaned her off the Statin as we felt the risk outweighed the benefits for her — at 84 my mom’s cholesterol is a low 145 (My note: this is too low a cholesterol reading) she weighs a mere 120 lbs, and her lifestyle has improved greatly from 2005 when she started with Statins. She’s on other heart meds and also on the diabetic drug Metformin for decades now, but no longer has risk factors for diabetes and we felt it was ridiculous to keep taking it. Sounds reasonable enough to monitor her blood sugar and go from there!

The doctor took all this to mean that we were questioning her ability as a doctor and flew off the handle at us, in a BIG way, accusing us of sabotaging our Mother’s health! She insisted our reasoning was off-base, saying what she was doing is science and it’s working. Who were we to question it?! She basically scared my mom into believing she would die without all her drugs and they want to give her more!

The Medscape article about this 17,000-person study published in Gastroenterology, mentioned that “concerns have been raised regarding potential harms linked to long-term use.” However, this new study “found that for the most part, use of PPIs was safe and generally was not associated with the adverse events observed in other studies.” Again, if you aren’t in the group that’s not harmed and in the group that’s harmed, how does that make everything OK? There are critics that agree with me and say the drugs can still be harmful and doctors shouldn’t ignore that fact. Also, the study only ran for 3 years and many people are on PPIs for a lifetime. 

PPIs and Magnesium 

One major side effect that can lead to 65 disease conditions is the 2011 FDA warning that GERD Drugs May Deplete Magnesium.  I know all drugs can deplete magnesium but for PPIs to impress the FDA enough to create a black box warning, you know something is seriously wrong. Some PPIs like Prevacid are fluoride drugs containing fluoride molecules. Clinically I see people developing serious magnesium deficiency when they take fluoride drugs because the fluoride molecule can irreversibly bind magnesium. 

In my 2013 blog “Fluoride Kills Magnesium” I warned that fluoride is in about 50% of prescribed drugs making them extra toxic in they way they disrupt magnesium biological processes. Here are the facts:

1. “Fluoride ion clearly interferes with the biological activity of magnesium ion.” And since magnesium does so much in the body, the side effects are often too widespread to recognize or even quantify.

2. One of the prime locations of possible fluoride (F) and magnesium (Mg) interactions is the intestines. The increased F supply reduces intestinal Mg resorption, owing to high chemical affinity of both elements and production of MgF+ and MgF2.” When I read this, I realized that’s another reason why ReMag in it’s Pico-Ionic form works so well because it’s absorbed directly into the cells and doesn’t reach the intestines and therefore is not inhibited in its activity by fluoride. Fluoride levels are rising because it’s in our drinking water and in everything made or mixed with water.

3. “The toxic effect of fluoride ion plays a key role in acute Mg deficiency.” This means if someone is already magnesium deficient, fluoride toxicity is more pronounced. That’s why some people are damaged by the antibiotic Cipro and others aren’t.

4. “Mg deficiency in plants may limit synthesis of chlorophyll, on which photosynthesis depends. Therefore, supplementation of Mg protects plants against toxic effects of fluoride compounds.” I’ve noticed a huge improvement in my outdoor plants since I’ve been applying magnesium to counteract the effect of fluoride in the water.

5. “Mg deficiency in animals reduces production of energy, relevant to the Mg-ATP system. Reduction of ATP levels affects in an unfavourable way many metabolic processes connected with the action of ATP (eg, metabolism of carbohydrates, proteins, nucleic acids, lipids, and active transport).” That statement speaks for itself.

6. “In summary, it can be stated that in intoxication with fluorine compounds, magnesium plays a protective role by countering and reducing the toxic effects of F.” Someone once asked me why she should spend money to take magnesium when it was just counteracted by fluoride! That’s like saying we shouldn’t bother eating because we just get hungry again. Magnesium will protect us against the toxic effects of fluoride and many other toxins.

Avoiding sugar and brushing your teeth after carbs and soda do much more for your teeth than fluoride. Even if fluoride gave some minor reduction in cavities it’s not worth it once you realize fluoride in any form kills magnesium.

FDAs Warning About PPIs and Magnesium, 2011.

Use of proton pump inhibitors (PPIs) regularly for a year or longer may lead to low levels of circulating magnesium, which may increase the risk of leg spasms, arrhythmias, and seizures, according to an FDA warning.

The FDA noted that PPI-associated hypomagnesemia was generally reversed with magnesium supplements, but in about 25% of cases “magnesium supplementation alone did not improve low serum magnesium levels and the PPI had to be discontinued.”

The FDA’s notice included the prescription drugs: esomeprazole magnesium (Nexium), dexlansoprazole (Dexilant), omeprazole (Prilosec), omeprazole and sodium bicarbonate (Zegerid), lansoprazole (Prevacid), pantoprazole sodium (Protonix), rabeprazole sodium (AcipHex) and the combination product esomeprazole magnesium/naproxen (Vimovo).

Also included were OTC formulations of the drugs: Prilosec OTC, Zegerid OTC, and Prevacid 24-hour.

The FDA warning follows reports that PPIs given to patients who undergo stenting and other percutaneous cardiovascular events may increase the risk of heart attack or stroke.  

Moreover, there have been reports linking PPI use to increased risk of Clostridium difficile diarrhea.  

The latest alert from the FDA says physicians “should consider obtaining serum magnesium levels prior to initiation of prescription PPI treatment in patients expected to be on these drugs for long periods of time.”

The risk of hypomagnesemia may be greater when PPIs are given to patients who are already taking drugs that are known to deplete magnesium, including digoxin and diuretics. For patients taking digoxin, a heart medicine, this is especially important because low magnesium can increase the likelihood of serious side effects.

The PPI side effects that are being swept under the table are not just an episode of nausea or a slight headache for drugs that are going to be used for a couple of weeks. We’re talking about osteoporosis related fractures, Clostridium difficile infection, pneumonia, GI infections, heart attack, kidney disease, gastric cancer, and increased mortality in drugs when they are taken for decades.

One researcher said “We can’t say that there is no harm whatsoever, because you can’t say that about any drug,” And there’s the rub. No drug is completely safe – and that’s what the public has come to expect, accept, and ignore.

The biggest critique of this 17,000-person study is that it was not designed to look for PPI side effects at all so it didn’t see them. Yet it’s being compared to studies of hundreds of thousands of people who were followed for up to a decade, who were harmed. The 17K study was set up to investigate cardiovascular outcomes with the blood thinner rivaroxaban (Xarelto), with and without aspirin. The PPIs were an add-on to prevent gastric bleeding from aspirin. The exact words of one epidemiologist were “This is way underpowered to tell us anything of consequence. PPIs are overprescribed and overused. We advise people to take PPI only when needed, for the shortest duration of time and the minimum dose necessary. The risk of adverse events is significant, and especially so in patients who are on PPIs but do not need them.”

The lead author of the study is funded by not one but three drug companies, all of which make PPIs and have vested interests in convincing the public that their drugs are safe. BAM!

What can you do if you have GERD and don’t want to become “addicted” to a PPI?  Here are the recommendations that I’ve laid our in my free Future Health Now Encyclopedia. It’s the very latest edition that includes Whole C ReSet and Flora Revive that should be in our online store shelves in September or October 2019.


Digestive disorders include gastritis, hiatus hernia, gas, bloating, bowel cramping, constipation and diarrhea. However, most of these conditions are also detailed in their own sections under Hiatus Hernia, IBS, Constipation, and Diarrhea. This section discusses how our digestion works and how to prevent digestive problems.

Even if you eat an optimum diet, there is still the question of proper digestion and absorption of those foods. The most important factor in digestion is proper food selection, avoiding non-nutritive junk foods, and choosing foods that provide the building blocks your body needs.

The second most important aspect of digestion is proper chewing. If you chew each mouthful of food thirty to forty times, this stimulates the salivary amylase enzyme in the mouth and one-third of the digestion will be done there. If you gently chew and hold cooked grain in your mouth long enough, it will become sweet. This is the action of the amylase breaking down the starchy carbohydrate into glucose.

The action of chewing also stimulates stomach acid production. If you are under stress or are generally tense, the stomach muscle, like any other body muscle, can go into spasm. This spasm can cut off blood circulation in the stomach and inhibit the production of stomach acid. This reduction in stomach acid can lead to improper or incomplete breakdown of stomach contents, especially protein. If incompletely digested food finds its way into the intestines, the intestinal flora (bacteria and yeast) will feed on this food and create gas and bloating. Incomplete protein digestion can be diagnosed by a urine test called Urine Indican. Most alternative medicine doctors are aware of this test, which is done in specialty labs. See the Resources section for a list of labs.

The third most important aspect of digestion is to avoid drinking water with a meal, especially ice water. Washing down each bite of food with water dilutes stomach acid and leads to incomplete digestion, washing food out of the stomach too soon. Cold water also causes fats and oils in the food to cling together, which impedes their absorption. You may drink water ten minutes before or two to three hours after eating.

After passing through the stomach, the food reaches the small intestine, where bicarbonates neutralize the pH of stomach acid and allow pancreatic amylase enzyme to further break down carbohydrates. Also, bile, from the liver and gall bladder, is excreted into the small intestine to emulsify fats. If there is insufficient amylase, undigested carbohydrates will provide food for intestinal flora in the gut. Carbohydrates, when digested by yeast, produce alcohol and acetaldehyde, which, in extreme cases, may cause someone to appear drunk. If fats are not absorbed, the stool is bulky and floats.


If food allergies are suspected as a cause of digestive problems, follow the advice in the section on regarding Food Elimination & Challenge. Yeast can also cause considerable gastrointestinal upset. Read The Yeast Connection and Women’s Health (Crook & Dean 2005) and refer to the Yeast Overgrowth section.

First Aid:

* Sodium bicarb: Also called bicarbonate of soda, one half to one teaspoon in a glass of water can help neutralize stomach acid,   allergic reactions, or yeast toxins. However, don’t use it frequently because it can diminish the digestive ability of the stomach acid.

* Charcoal tablets treat gas with a foul odor by absorbing toxins in the intestines that are eliminated in bowel movements. They may turn the stool black.

*Bentonite clay: Liquid, food grade clay, absorbs toxins, and can be used in detox formulas. See Cleansing.


ReMag, a 100% absorbed, bioavailable, non-laxative magnesium. Dosage: ½-1 tsp twice per day. This mineral drives 700-800 enzyme systems and is responsible for the production of energy in the body. Click on the Books link at Dr. Carolyn Dean Live to download the free eBook, ReMag: Invisible Minerals Part I. Make sure to take enough magnesium to maintain an optimum level of Magnesium RBC at 6.0-6.5mg/dL.

ReMyte multiple mineral, which contains 12 complementary minerals. Dosage: ½ tsp three times per day. Click on the Books link at Dr. Carolyn Dean Live to download the free eBook ReMyte & ReCalcia: Invisible Minerals Part II.

* Vitamin B complex: Use ReAline: Contains several methylated and food-based B vitamins along with L-methionine and L-taurine from natural souces. It is a safe, natural detoxifier that assists any condition. Dosage: 1 capsule twice per day.

* Vitamin C with bioflavonoids: Strengthens blood capillaries and reduces menstrual bleeding. Use Whole C ReSet, a food-based, organic Vitamin C and one of our Completement Formulas. It supports the structure and function of connective tissue and helps repair worn out adrenal glands. Dosage: One tablet, once or twice daily.

* Probiotics: This supplement replenishes the intestines with good bacteria that help digest and absorb food and give bulk to the stool improving transit time. I recommend Flora ReVive. Dosage: Take one capsule on waking and one capsule at bedtime. Best taken on an empty stomach, 30 minutes away from food. However, it can be taken with food and it does not require refrigeration. If you have a sensitive gut, you may begin by taking one per day for one week before adding the second capsule of Flora ReVive.

RnA ReSet Drops: A unique product made from barley sprouts that produces a unique cell called the iCell, which helps make perfect cells and balances body, mind, and spirit. I describe them on page 14 of this book and you can also go to RnA ReSet for dosage instructions and more information.

NOTE: Over the 9 years of making RnA ReSet Drops, 142 of 144 RnA ReSet batches did not show gluten, however, because of those 2 positive tests, we choose to declare that we are not gluten free on our label. 

Blue Ice Royal: Fermented Cod Liver Oil and Butter Oil provide balanced doses of Essential Fatty Acids, Vitamin D, Vitamin A, and Vitamin K2. Dosage: 1 capsule twice per day or ½ tsp per day.


* DGL licorice (de-glycyrrhizinated removes the aspect of licorice that may cause fluid retention and high blood pressure) is the treatment of choice for stomach upsets including Heartburn.

* Swedish bitters are bitter herbs in an alcohol base that stimulate digestive juices and help relieve gastritis.

* Mint tea is soothing for the stomach and intestines.


* Nux vomica: For overindulgence in food or drink.

* Lycopodium: For queasiness after eating heavy fatty meals.

Both remedies can be used in the 12X potency taken every hour as needed but should be stopped if they have not provided relief within 48 hours at which time a homeopath should be consulted.

If you want more information on PPI’s you can read several of my blogs or guest blogs.

·  Proton Pump Inhibitors – Fact or Fake?

·  Acid Blockers Block Everything!

·  Heartburn Drugs Burn the Heart

·  Why Kill Your Stomach Acid?

Learn about magnesium, and much more, by subscribing to my health tips by email. You can subscribe here: https://drcarolyndean.com/subscribe

Carolyn Dean MD ND

The Doctor of the Future®

RESOURCES: Along the borders and in the links of my web site you can find my books, writings, and my call-in radio show. Email your questions to: questions@drcarolyndeanlive.com.

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