Magnesium or Biologics for Inflammation - Dr. Carolyn Dean MD ND

Magnesium or Biologics for Inflammation

September 8, 2019

Inflammation is a major cause of chronic disease; I’ve been saying this for years and now allopathic medicine is agreeing. If you Google my name and inflammation you’ll access a whole screen-full of blogs like “Excess Calcium Fuels Neuro-Inflammation.” “Magnesium The Safe and Natural Anti-inflammatory” In my Magnesium Miracle book I mention inflammation 93 times. I’ve also warned that drug companies are constantly looking for “safe” anti-inflammatory drugs. They struck out with the NSAIDs (non steroidal anti-inflammatory drugs) because they cause so many side effects – the worst of which is heart disease – likely driven by magnesium deficiency. 

Biologic Monoclonal Antibodies

Because nothing else was working, the latest so-called “breakthrough” in the anti-inflammatory market is monoclonal antibodies. As with many new classes of drugs, they began as cancer drugs, likely because cancer is so deadly that a lot of corners are cut to release drugs that may help. Once on the market, it’s not long before these “last resort” drugs become mainstream. And you can’t get more mainstream than a drug to treat inflammation.

Monoclonal means they are focused on one variety of cells. In the case of inflammation, that would be cytokines, chemokines, adhesion and co-stimulatory molecules – anything that drives inflammation. Of course killing off a cell line is not to be taken lightly. It’s a given that something beneficial in that cell line is also being terminated.

Biologic Medicine

On my June 24, 2019 online radio show, Dr. Carolyn Dean Live I delivered a rant on Biologic Medicine that I’ll repeat here:

I became aware of the pervasiveness of biologic drugs when I did my 50 hours of continuing medical education credits for my California license. I don’t practice in CA but I maintain my license to force myself to do the CME credits to keep up with medical trends.

Well the trend is that allopathic medicine has given up on treating chronic diseases that I say are caused by nutrient deficiency and yeast overgrowth because the decades of treating them with chemical drugs is not working. Big Pharma is now focused on using what they call biologic drugs. They are going after very complex diseases like autoimmune disease and cancer, which have in part, been created by allopathic medicine because of the overuse of drugs and because they don’t recognize nutrient deficiencies and yeast overgrowth. 

Yes, I’ve said for decades that autoimmune disease is caused by yeast overgrowth and magnesium deficiency. Cancer treatment has the added failure of allopathic medicine to look at the conflict basis of cancer that is described by Total Biology and German New Medicine.
I think the term Biologic Medicine was invented to make people feel warm and fuzzy about a type of medicine that implies that it’s working with nature. These drugs are cutting edge, complex, and costly compared to chemically-derived drugs.

I repeat, these drugs are being given in a climate of serious magnesium and nutrient deficiencies and yeast toxicity that make all the side effects of the Biologic Drugs much worse.

What is a biologic drug?

Most biologics are very large, complex molecules or mixtures of molecules produced using recombinant DNA technology.

According to a biologic drug is a product that is produced from living organisms or contains components of living organisms. They include a wide variety of products derived from human, animal, or microorganisms by using biotechnology. Types of biologic drugs include vaccines, blood, blood components, cells, allergens, genes, tissues, and recombinant proteins.

Biologic products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.
Biologic drugs are sometimes referred to as biologic response modifiers because they change the manner of operation of natural biologic intracellular and cellular actions.

What are the medical uses for biologics?

As I mentioned above, biologic drugs are earmarked for autoimmune disease, cancer, and rare diseases. They are said to be the most advanced therapies available. And, to repeat, they don’t touch the vast majority of diseases that are common to the population and are a result of nutrient deficiencies and yeast overgrowth.

Here are some examples of medical uses for biologic drugs:

Various cancers, RA, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, psoriasis, diabetes, multiple sclerosis, heart attack, lupus, macular degeneration, diabetic retinopathy, pneumonia, anemia, chronic migraine, hepatitis B, hemophilia, RSV, HPV, growth hormone deficiency, osteoporosis, allergic asthma, chronic urticaria, infertility, meningococcal disease, cystic fibrosis, paroxysmal nocturnal hemoglobinuria. 

What are the side effects of biologics?

  • Allergic hypersensitivity reactions – hives, itching, throat closing, anaphylaxis leading to death.
  • Immune system suppression which can be serious enough to reactivate Hep B and TB
  • Injection site reactions if given IM.
  • Infusion reactions in IV drugs

To merely say “immune system suppression” does not signify the seriousness of coming down with an infection in an already compromised patient. These infections – mild, moderate, or severe are all treated with antibiotics that actually makes an autoimmune condition even worse because antibiotics cause yeast overgrowth and unleash the 178 different toxic byproducts of yeast. 

Allopathic medicine underplays the threat with the following words. “Biologic medications help to control your inflammatory disease but also affects your natural ability to fight off an infection. If you get an infection while taking a biologic medication, you should let your doctor know right away so it can be treated. While on an antibiotic, you will likely pause your biologic medication until your doctor says you are able to resume your treatment.” 

Above are the 4 major side effects, however:

Less common side effects: possible central nervous system disorders, cardiac issues, and lupus-like syndrome.

Common side effects: chills, weakness diarrhea, nausea, vomiting, skin rashes, itching, high blood sugar, cough, constipation, SOB, edema, headache fever, fatigue, muscle aches and pain, decreased appetite, increased TGL, insomnia, abdominal pain, back pain, dizziness, low blood pressure.

Serious side effects: Low blood pressure, anaphylaxis, serious infections, cancer, serum sickness, autoimmune thyroiditis, arterial and venous blood clots, congestive heart failure, bleeding, interstitial lung disease, hepatitis, increased antibodies, enterocolitis, GI perforation, mucositis, stomatitis, anemia, reduced WBCs, hypothyroidism. 
The warnings continue with the following details:

  • Low blood cell counts. Monoclonal antibodies that deliver radioactive particles or chemotherapy drugs may be associated with low blood cell counts that can be severe and persistent.
  • Heart problems. Certain monoclonal antibodies increase the risk of high blood pressure, congestive heart failure and heart attacks.
  • Lung problems. Some monoclonal antibodies are associated with a higher risk of inflammatory lung disease.
  • Skin problems. Sores and rashes on your skin can lead to serious infections in some cases. Serious sores can also occur on the tissue that lines your cheeks and gums (mucosa).
  • Bleeding. Monoclonal antibody drugs designed to stop cancer from forming new blood vessels have an increased risk of severe internal bleeding.   

Biologic drugs are administered by injection or infusion because they are proteins that are quickly digested and inactivated if given by mouth. Lord Sufferin’ Cats. You better believe that when foreign proteins come into the body the body’s natural reaction is to get rid of them because they are toxic and can set up serious antigen antibody reactions! Perhaps the people these drugs seem to work for are those whose immune systems are already beaten down so much that they don’t react normally to these drugs.

If you have to take these drugs, use them along with all the Completement formulas so that the body can start building new perfect cells. However, I’m also saying that people on the Completement Formulas may not have to go to Biologic Drugs in the first place.

What’s the immediate downside of an injection? The full dose is in the body and can’t be counteracted. To avoid full dose reactions we constantly tell people to start any new supplement at a very low dose and raise the amount very slowly. There is no such commonsense advise in the administration of biologic drugs.

Who Voted for Biologics?

I wrote a May, 2017 blog called “Who Voted for Biologics? that I want to quote and update.

Drugs generally have well-defined chemical structures, and a finished drug can usually be analyzed to determine all its various components. By contrast it is difficult, and sometimes impossible, to characterize a complex Biologic by testing methods available in the laboratory, and some of the components of a finished biologic may be unknown. The living systems used to produce Biologics can be sensitive to very minor changes in the manufacturing process. Small process differences can significantly affect the nature of the finished biologic and, most importantly, the way it functions in the body.

How do you feel about taking drugs that are so complex that they can’t even be identified after being manipulated inside other living organisms; using recombinant DNA; and with no clue how they might function in the body where a small change can occur in the dozens of steps to produce it? Phew! Think Frankenstein’s monster. I’m sure most people who are taking these drugs don’t even know they are on Biologics – until they develop the side effects.

How about manipulating your own cells with the right building blocks? Now there’s a thought!

Here are some reports we have gotten from customers: 

            I have taken Prolia (a biologic for osteoporosis) with disastrous results. I am in constant pain, my balance is terrible (it’s not vertigo), I have tremors and edema – to name a few. My third and last injection was in June. They last 6 months. I have been on ReMag and ReMyte for almost a week. I’m already sleeping better but I wanted to know if you have any other suggestions for what is happening to my body. I hardly eat any sugar including fruits. I avoid gluten and dairy. I am not overweight and was in good shape before this all started. Now I walk with a walking stick and can barely do anything.

I told her that I would increase ReMag to 3-4 tsp a day and ReMyte 2 tsp a day and take ReAline, 1 capsule twice a day to help detox the drug faster. I would also use Pico Silver, 2 tsp a day to help with stem cell production and to boost the immune system.

            My 39-year old daughter started taking ReMag approximately 3 weeks ago. I’ve been telling her since I started on it over a year-and-a-half ago that this was so necessary for her body, however she is on over 24 prescription medications and she just did not want to add anything else. She is currently drinking two 1/2 teaspoons of ReMag daily. She has been bald for several years now and in the three weeks that she has been drinking ReMag she has grown peach fuzz all over her head and we are elated!”

Or try and wrap your mind around the following horror story!

            “My husband had a heart attack a little over a month ago. His young, very aggressive cardiologist put him Metoprolol, Spironolactone, Amiodorone, Losartan, Warfarin, and Plavix. He is diabetic and asthmatic and was already taking Metformin, Glimerpiride and Ventolin. 

He went in for a check up this Friday and we told the doctor all my husband’s side effects. He is terribly constipated with hard dry stools almost impossible to pass. His gums and nose are starting to bleed. He has indigestion with burning in his throat. He’s very dizzy first thing in morning. His restless legs are getting worse. His heart, which is also in AFib has now developed a flutter as well. His potassium is rising. His kidneys are losing some function. This is in only one month’s time. 

The doctor says he realizes my husband is having side effects but because of his AFib he is afraid to take him off anything yet for fear he will have a stroke if his pulse goes too high. It was running 137 in doctor’s office but we told him it was nerves because at home it runs in 60’s to 80’s or low 90’s. He wants to put him on a 48-hour holter heart monitor and do an echocardiogram before he changes anything. We can’t get either one of those done until June 5, and June 14. So that’s another month of side effects building up. 

He also wants my husband to consider a cardiac ablation for his AFib. He has forbidden him to use any supplements. Interestingly, years ago, my husband used to take me to the emergency room with ventricular tachycardia. I was put on Cardizem and switched to Hydrochlorothiazide and Verapamil. Later I saw a naturopath who told me I needed magnesium and I quit taking the doctors meds and only took magnesium faithfully. I never went to emergency room again. That was 20 years ago.”

I wrote back immediately and said the cause of the rising potassium could be the diuretic Spironolactone, which is a potassium-sparing water pill that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low! I said, if you are concerned about elevated potassium, I would ask to be taken off that drug.

I was shocked that he was on TWO blood thinners Plavix and Warfarin. That could be why he’s bleeding and, I said, I’m concerned that he might bleed from rectal tears caused by his severe constipation! I expressed my concern that her husband is being poisoned with too many drugs and recommended they change doctors as soon as possible.

The 39-year old woman is probably on Biologic drugs – especially because of the side effect of hair loss. The 69-year old gentleman is not on Biologics. However, Biologics would be the next drug they offered him as they ignore the drug side effects and just think it’s a progression of his disease. After all, that’s what the continuing medical education classes recommend – More Biologics! 

Biologics for Inflammation 

Big Pharma enthuses that:

            monoclonal antibodies (mAbs) are antibodies of a single antigen specificity produced by identical immune cells, i.e., clones of a common germ cell. They offer unprecedented opportunities to drug development because of their ability to target almost any cell surface or secreted molecule with remarkable efficacy and safety.

They say that for inflammation 

            …a large variety of monoclonal antibody-based agents targeting a plethora of cytokines, chemokines, adhesion and co-stimulatory molecules, receptors, as well as diverse cell types, are presently under investigation, the therapeutic armamentarium of the clinician is expected to greatly broaden in the near future, providing improved patient care for a wide range of devastating diseases of our times.

Big Pharma has obviously learned nothing from the antibiotic resistance crisis where these drugs kill any bacteria in their path – good or bad – leading to yeast overgrowth, leaky gut and small intestine dysbiosis. With the same cavalier attitude as they have with antibiotics, they imagine that biologic drugs will only affect the cells they designate and go no further. And nothing could be further from the truth.

In spite of all the side effects, medicine seems to be in favor of these new drugs and accepting the consequences of side effects on behalf of their patients. And for the most part patients seem to accept drug side effects as normal. The average number of side effects for prescription drugs is 150. You can count them yourselves. Drug companies are careful to list all the possible side effects probably because it protects them from lawsuits. If someone complains of a side effect – their lawyers just have to say – they are listed in the indecipherable print on the packaging insert.

Ilaris – A Pure Anti-inflammatory Drug

The monoclonal antibody, Ilaris has been touted as the next breakthrough in cardiovascular medicine. It fascinates researchers because they say it reduces major cardiovascular events but doesn’t do it by lowering cholesterol. I’m quoting from a paper called “New Treatments in Cardiovascular Medicine” that reported on the results of a drug trial at the European Society of Cardiology in Barcelona. Desperate for some positive therapies for cardiovascular disease, the paper enthused about this “pure anti-inflammatory strategy” saying that “It’s a new window opening on another approach to treatment. And we’re very excited about the results.”

Not too exciting is the cost for Ilaris. It’s an injection at an outrageous price of $16,770 per monthly shot. It was first unveiled as a treatment for a rare children’s disorder. Immediately on gaining that approval the company making Ilaris applied for approval in heart disease. 

I started researching Ilaris, the new wonder drug for inflammation about a year ago. And just like I’ve said before, monoclonal antibody drugs get in the door by claiming to be cancer drugs and then apply for broader usage. In the fall of 2018, MedPage reported that the “FDA  Rejects Canakinumab in CVD Prevention.” The FDA notice said that “The $200,000-a-year interleukin-1β inhibitor had been approved in 2013 for certain rare inflammatory disorders.” When they applied for cardiovascular approval it was based on “15% reduced cardiovascular events among more than 10,000 patients with a history of myocardial infarction followed for 3.7 years.” They saw this as some sort of validation of the inflammation hypothesis in heart disease, though the effect was very weak and the drug made “no noticeable dent in all-cause mortality.”

Against all commonsense and sanity Big Pharma would rather spend a billion dollars pushing a drug that might help 15% of the heart disease population – that could afford $200,000 a year – instead of researching magnesium. I’ve already mentioned the side effects of monoclonal antibody drugs and Ilaris is no different. It depresses your immune system lowering your ability to fight infection. Pneumonia, bone and joint infections, skin infections and sinusitus are mentioned and will all require lots of antibiotics.

As I say in my 2014 blog “Magnesium The Safe and Natural Anti-inflammatory”: 

            Instead of drugs to suppress the body’s natural reaction to injury and stress, I highly recommend oral and topically applied ReMag. ReMag does dozens of things for inflammation; it increases circulation to the area and stimulates the detoxification pathways of the liver. Most importantly, it directs the production and function of nitric oxide, which is a signaling molecule that has an anti-inflammatory effect under normal physiological conditions. An abnormal physiological condition is when there is not enough magnesium to make enough nitric oxide to do its work, and inflammation is not controlled. It also keeps pro inflammatory calcium in solution and directs it away from soft tissues and into the bones and teeth.

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Carolyn Dean MD ND

The Doctor of the Future®

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