The People of the Maui ReSet Pilot
Ten everyday people, ages 34 to 79, numbers and confounders included.
Ten everyday people, ages 34 to 79, followed the same daily nutrient protocol for six months while living ordinary lives, with real stress, real health histories, and in a few cases real setbacks along the way. Here are all ten, numbers and confounders included. Names are pseudonyms to protect privacy, and every experience is that person’s own. Individual results vary.
Biological age is the focus compared to chronological age. How fast or slow we age is the “pace of aging” and that’s what we want to influence.
What we saw across the group
Symptoms. Self-reported symptom scores improved across all participants.
TruAge. Nine of the ten showed favorable movement in their biological-age metrics over the six months.
TruHealth. All ten showed favorable movement across at least some key epigenetic biomarkers.
TruAge. Nine of the ten showed favorable movement in their biological-age metrics over the six months.
TruHealth. All ten showed favorable movement across at least some key epigenetic biomarkers.
| Biomarker category details (TruHealth) | What it relates to | Range of improvement observed |
|---|---|---|
| Vitamins | Nutrient repletion | up to +26 percentile points |
| NAD+ metabolism | Cellular energy and longevity | up to +42 |
| Mitochondrial function | Cellular energy production | up to +55 |
| Stress markers | Cortisol and inflammatory stress | up to +58 |
| Antioxidants | Oxidative defense | up to +25 |
| Immune markers | Systemic immune resilience | up to +34 |
| Ketones | Metabolic flexibility | up to +69 |
| Neurocognitive markers | Brain health and cognitive resilience | up to +28 |
The ten stories
Helen, 70
Essentially housebound with nerve and muscle symptoms she feared were neurological disease. Blood drawn at home because she couldn’t come to her appointment with us. Her OMICm Age reading was 63, lower than her chronological age of 70. But over the 6 months she slowed her age to 58. Her self-reported symptom score fell by about 55 percent, and her ketone and immune markers rose sharply. In her words, she can drive and walk again. Her energy, she says, is now “fabulous.”Claudia, 53
Three decades of antidepressant use and a long history of anxiety, worry and fatigue left her feeling, in her words, paralyzed. Her baseline biological-age reading already sat below her chronological age, and she still improved a further 4.5 years. Her symptom score fell by about 40%. “My brain has changed,” she said. Her weight dropped 30 pounds.Suzanne, 50
In spite of an outwardly upbeat person she was troubled with anxiety, worries, stress at home and in the workplace; she felt hopeless. She reported that her confidence soared, she had steadier energy, better sleep, and a more hopeful outlook. Her symptoms improved 79%. Her OMICm reading moved from 52 to about 47.5 and her Symphony reading from 51.5 to 48.2. Any medication adjustments during the study were directed by her physician and are not attributed to the protocol.Sarah, 79
The oldest participant, living with lifelong heart disease. She was hospitalized mid-study and still proved resilient. Her Symphony reading moved from 85 to 81, most of her organ-system ages sat below her chronological age, and her mitochondrial marker climbed from 14 to 62 percent. She wants to keep going on the formulas and is very upbeat.Arlene, 51
Navigating heartbreak and a high-stress new job, living on fast food and poor sleep, and, yet, she still thrived. Her OMICm reading moved from 45 to 41 and her symptom score fell by about 62 percent. She reported better sleep from the second night of the study.Emily, 48
A strong baseline with the stress of a relationship breakup as her weak point, plus an acute glaucoma episode mid-study. She held her ground on the clocks under real strain, and her symptom score fell by about 75 percent. Her stress showed up fully as her stress markers rose from the 11th to the 81st percentile, one of the sharpest single shifts we saw.Pauline, 56
Works in the wellness field and took three unexpected mainland trips to be with a dying mother during the study without ever missing a dose. Her symptoms spiked with travel and then settled, her thyroid markers normalized, and several depleted B vitamins refilled. A clean illustration of how travel stress shows up in the data and then recovers.Grace, 53
Moving through a turbulent hormonal transition from stopping birth control to a hormone replacement prescription took its toll. Her OMICm and Symphony scores suffered but her subjective symptom score netted an improvement of about 43 percent after a mid-study spike. The nutrient foundation appeared to work alongside her physician-directed hormone care.Steven, 34
The most complex case, with a history of one year of antibiotics and ADHD medication as a child, a difficult substance abuse history and an unapproved harsh detox during the study that put him in the hospital. We kept him on the foundational nutrients to try and help him and observe the response, and report the full picture. His symptom score actually improved by about 53 percent, while his biological-age readings actually moved older over the six months. That is consistent with an intense healing and detox transition, where the body mobilizes and clears a large burden before deeper markers settle.James, 77
A veteran with Agent Orange exposure, small-fiber neuropathy, tinnitus, and severe fatigue. His symptom score improved substantially, his mitochondrial marker climbed from the 20th to the 75th percentile, and his Symphony reading eased from 72.5 to 71.1. He reports full days gardening again but admits that he’s so excited about his newfound energy that he can tend to overdo it.Important disclosures
Individual results vary. These statements have not been evaluated by the Food and Drug Administration. The Maui ReSet Pilot Study is a real-world observational pilot (n=10) and is not a randomized controlled trial. Results are hypothesis-generating and should not be interpreted as clinical proof of efficacy. Participant names are pseudonyms. Any medication changes mentioned were directed by the participants’ own physicians and are not attributed to the protocol. Always consult your healthcare provider before beginning any new dietary supplement or wellness program.
Keep Going
These are real people who followed the daily foundations for six months. Here is how to go deeper into the program they followed.