The Maui ReSet Pilot Study
Supporting a Healthy Aging Trajectory Through Targeted Cellular Nutrition
The Goal is to Reduce Your Biological Age by Slowing the Pace of Aging with the Right Nutrients
Over six months on Maui, ten everyday people, ages 34 to 79, followed the same daily nutrient protocol. A finger prick blood test before and after the 6 months study measured Age and Health Factors via epigenic methylation testing.
This page tells the whole story: what we did, what we say, and how my fifty-year career led to the formulas at its center.
What we set out to observe
What I wanted to document
I wanted to do an in depth survey of my customer base to see how their health improved on my formulas. Our research director, who ran the Purdue ReMag Absorption Study in 2020 said it wouldn’t fly, we had to do a study with before and after testing. He was all fired up about the new epigenetic methylation testing and we realized that we could do a small pilot study right here in my own backyard.
The question was simple to ask, and I’ve been asking it for decades. When the body is given consistent, highly absorbable nutrients at the cellular level, we should see health benefits. And now with standardized epigenetic testing, we will be able to measure the biomarkers that track how a person is aging?
We chose a defined daily nutrient protocol. We recruited real people living real lives, with real stress and real health histories. And we measured them with an independent testing partner, before and after, so the numbers were not ours to grade.
The study at a glance
| Duration | August 2025 to February 2026 (six months) |
| Participants | 10 adults, ages 34 to 79, from a farm store, a farmer’s market, and the wellness community on Maui |
| Testing partner | TruDiagnostic (independent), TruHealth and Advanced TruAge panels |
| Clocks measured | OMICm Age (Harvard), Symphony Age (Yale’s 11 organ-system clock), and DunedinPACE (pace of aging) |
| Formulator | Dr. Carolyn Dean MD ND |
| Compliance | self-reported, with general healthy-eating guidance and no forced dietary changes |
| Assistant | Julie Simon |
What the tests actually measure
Epigenetic clocks read chemical tags on your DNA, called methylation, that shift in patterns as you age.
Two ideas matter here:
Biological age
A snapshot estimating how hold you are biologically right now compared with your chronological age.Pace of aging
This is an estimate of how fast you are aging in real time. Are you burning through life hard and fast or nice an slow giving you “time” to smell the roses.We went all out and used three clocks:
OMICm Age is how old the body looks overall, apparently with the help of AI surveying 800,000 methylation receptor sites.
Symphony Age shows which of eleven organ systems are aging faster or slower.
DunedinPACE is how fast you are aging right now, the speedometer, and the one sensitive enough to move within about three months.
To be clear, these are not diagnoses, they are risk-and-trend assessments.
The bigger picture: Where is this testing being used?
In 2026, a large randomized controlled trial called COSMOS (n=958) reported that a daily multivitamin-mineral taken over a period of 2 years slowed the rate by a mere 4 months. It’s being touted as a well-designed, independent evidence that multiple nutrients are associated with aging biology.
Our pilot expands to an array of nutrients delivered in highly-absorbable picometer ionic forms to ask if we can move that needle meaningfully in an even shorter time? The two studies used different clocks (but they are all epigentic methylation clocks) and very different designs, so they are not directly comparable, and we never present ours as beating a randomized trial. We show the parameters side by side, and let them stand.
What the pilot involved
| Design | Uncontrolled observational pilot, n=10 |
| Duration | 6 months |
| Clocks measured | OMICm Age, plus DunedinPACE |
| Reported change | Favorable OMICm shifts in several participants, no control group |
| Absorption | Stabilized picometer ionic minerals (see our ReMag Absorption Study Purdue 2020). We also used food-based vitamins, low-potency food-based methylated B vitamins, which tend to be well absorbed. |
A pattern in the sequence of change
1. Symptoms ease first
Often within the first one to two months: less fatigue, less brain fog, steadier mood, fewer aches. In some participants it was in the first several weeks.2. Organ-system markers shift next
With the final testing, we saw improvements in the Yale eleven-organ click where the organ system improvements seemed to be greater than the OMICm Age markers.3. The deepest clock moves last
The whole-genome reading (OMICm Age) seemed to move to a lesser extent than the organ clock because it reflects the slowest, most fundamental layer. And we did only run the study for 6 months.The practical implication is that six months may be too short to capture the full arc. If symptoms improve first and the deep clock moves last, a twelve-month protocol would give that deepest layer time to catch up. That is the central argument for a longer, larger, controlled study, which is exactly what a pilot like this exists to justify.
Meet Our Maui ReSet Participants
With their individual stories, their ups and downs, and varying results
Meet the ten participants
All ten stories, numbers and confounders included.Start the 90-Day ReSet
Discover, optimize, verify: the same path the study followed.The TruDiagnostic test is not required but if you would like to do your own pre- and post-test with an in-home finger prick blook test, click here for the TruDiagnostic website.
The formulas, and the physician behind them
Dr Dean is a medical doctor and naturopath whose fifty-year career has centered on how minerals an nutrient sactually reach the cell. The four liquid minerals use stabilized picometer ionic forms that are the perfect size to be absorbed through the pciometer-sized, cell mineral ion channels. The three nutrient capsule formulas are food-based.
Two basic ideas explain why this set of formulas was chosen for a study about aging biomarkers. Minerals are the foundation the cell runs on, and magnesium alone participates in 600-800 enzyme reactions, including the systems that copy and maintain DNA.
The methylated B vitamins in the protocol feed one-carbon metabolism, the methyl-group system that supports normal cellular function, which is the same chemistry the epigenetic clocks read. We do not say these formulas treat or cure. These are nutrients that support the normal structure and function of the body’s own systems.
What this means, and what comes next
Summary Conclusion: A rigourous, randomized trial (COSMOS) has shown that a basic multiple vitamin/mineral can move epigenetic aging clocks. Our small pilot, using highly-absorbable forms of vitamins and minerals, saw very favorable trends in most of ten real people over six months, alongside a consistent pattern where symptoms eased first and the deepest clock moved last. That pattern suggests a longer study would likely show even more beneficial results at the deepest layer. It is a hypothesis worth testing at scale, and that is why pilot studies exist.
If the approach makes sense to you, the path is the same one the study followed:
- Discover where you stand, with a baseline biological-age reading.
- Optimize with consistent, high-absorption nutrient support and healthy daily habits.
- Verify by measuring again and watching changes.
Your biology is a snapshot today. The trend is the part you get to work on.
Important disclosures
About the study. This content is for informational and educational purposes. The Maui ReSet Pilot Study is a real-world observational pilot (n=10) and is not a randomized controlled trial. Results are hypothesis-generating and should not be interpreted as clinical proof of efficacy. Howeverr, it is a “powerful proof of concept” study – the concept being that a group of basic nutrients, taken regularly, can be the longevity solution that many are seeking.
All formulas described are dietary supplements that support the normal structure and function of the body. They are not intended to diagnose, treat, cure, or prevent any disease.
Dr. Carolyn Dean is the founder and formulator of the nutrient line used in this study and holds a creative and economic interest in those products. Biological-age testing was performed by TruDiagnostic, an independent testing partner. These statements have not been evaluated by the Food and Drug Administration. Always consult your healthcare provider before beginning any new dietary supplement or wellness program.